How Many Thymocytes Audition for Selection?

How Many Thymocytes Audition for Selection?

T cell maturation requires the rearrangement of clonotypic T cell receptors (TCR) capable of interacting with major histocompatibility complex (MHC) ligands to initiate positive and negative selection. Only 3-5% of thymocytes mature to join the peripheral T cell pool. To investigate the basis for this low success rate, we have measured the frequency of preselection thymocytes capable of respond...

How many rounds can Random Selection handle?∗

The construction of zero-knowledge proofs is greatly simplified if the protocol is only required be secure against the honest verifiers. Damg̊ard, Goldreich and Wigderson invented an technique, called Random Selection, to transform a public-coin honest verifier zero-knowledge protocol to a general zero-knowledge protocol [3]. However, it has been widely assumed that the technique itself only wor...

Development and selection of T cells: how many subsets? How many rules?

Since the discovery indicating that thymus-derived lymphocytes (T cells) can be divided into two subpopulations: CD8+ (killer) and CD4+ (helper) cells, subsequent studies revealed a bewildering heterogeneity of T cells. In the present review an attempt is made to present the current picture of T cell heterogeneity, introduce some order into the nomenclature, and summarize the rules behind the d...

TCR- CDR3 Loop Audition Regulates Positive Selection

How many patients? How many doctors?

O ne of the fastest growing fields in medicine is the care of adults with congenital heart disease (adult CHD or ACHD). This is mainly a consequence of much longer survival due to advances in pediatric cardiology, interven-tional catheterization, cardiac surgery, and intensive care. Fifty years ago we could diagnose most forms of moderate and severe CHD, but some anomalies were untreatable and ...